MICRO-ENVIRONMENTAL MECHANICAL STRESS CONTROLS TUMOR SPHEROID SIZE AND MORPHOLOGY BY SUPPRESSING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS.

Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.

Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell phenotype, or the molecular pathways involved.We co-embedded single cancer cells with fluorescent micro-beads in agarose gels and, using conf

read more




Deterioration of autoimmune condition associated with repeated injection of dextranomer/hyaluronic acid copolymer: A case report

A 6-year-old girl underwent ureterocystoneostomy (UCN) because of left flank pain due to delayed onset of ureteral stenosis one and a half years after endoscopic dextranomer/hyaluronic acid copolymer (Deflux) injection for the treatment of vesicoureteral reflux (VUR).Histopathological examination indicated chronic inflammation with abundant eosinop

read more